The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs.

ABSTRACT:

Unlabelled

Non-steroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity drug reactions. Histamine is released in the allergic response to NSAIDs and is responsible for some of the clinical symptoms. The aim of this study is to analyze clinical association of functional polymorphisms in the genes coding for enzymes involved in histamine homeostasis with hypersensitivity response to NSAIDs. We studied a cohort of 442 unrelated Caucasian patients with hypersensitivity to NSAIDs. Patients who experienced three or more episodes with two or more different NSAIDs were included. If this requirement was not met diagnosis was established by challenge. A total of 414 healthy unrelated controls ethnically matched with patients and from the same geog

SUBMITTER: Agundez JA 

PROVIDER: S-EPMC3495953 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature