Serum cystatin C- versus creatinine-based definitions of acute kidney injury following cardiac surgery: a prospective cohort study.

ABSTRACT:

Background

The primary aim of this study was to compare the sensitivity and rapidity of acute kidney injury (AKI) detection by cystatin C level relative to creatinine level after cardiac surgery.

Study design

Prospective cohort study.

Settings & participants

1,150 high-risk adult cardiac surgery patients in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) Consortium.

Predictor

Changes in serum creatinine and cystatin C levels.

Outcome

Postsurgical incidence of AKI.

Measurements

Serum creatinine and cystatin C were measured at the preoperative visit and daily on postoperative days 1-5. To allow comparisons between changes in creatinine and cystatin C levels, AKI end points were defined by the relative

SUBMITTER: Spahillari A 

PROVIDER: S-EPMC3496012 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature