No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density.

ABSTRACT:

Introduction

Increased mammographic breast density is one of the strongest risk factors for breast cancer. While two-thirds of the variation in mammographic density appears to be genetically influenced, few variants have been identified. We examined the association of inherited variation in genes from pathways that mediate cell division with percent mammographic density (PMD) adjusted for age, body mass index (BMI) and postmenopausal hormones, in two studies of healthy postmenopausal women.

Methods

We investigated 2,058 single nucleotide polymorphisms (SNPs) in 378 genes involved in regulation of mitosis for associations with adjusted PMD among 484 unaffected postmenopausal controls (without breast cancer) from the Mayo Clinic Breast Cancer Study (MCBCS) and replicated the f

SUBMITTER: Vachon CM 

PROVIDER: S-EPMC3496122 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature