Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women.

ABSTRACT:

Introduction

Recently, several genome-wide association studies (GWAS) have identified novel single nucleotide polymorphisms (SNPs) associated with breast cancer risk. However, most of the studies were conducted among Caucasians and only one from Chinese.

Methods

In the current study, we first tested whether 15 SNPs identified by previous GWAS were also breast cancer marker SNPs in this Chinese population. Then, we grouped the marker SNPs, and modeled them with clinical risk factors, to see the usage of these factors in breast cancer risk assessment. Two methods (risk factors counting and odds ratio (OR) weighted risk scoring) were used to evaluate the cumulative effects of the five significant SNPs and two clinical risk factors (age at menarche and age at first live birth).<

SUBMITTER: Dai J 

PROVIDER: S-EPMC3496134 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature