Dataset Information
The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.
Ontology highlight
ABSTRACT:
SUBMITTER: Lindsey EA
PROVIDER: S-EPMC3496259 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.
MedChemComm 20120101 11
A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies reveal a zinc-dependent mode of action for these compounds. ...[more]