Recombination modulates how selection affects linked sites in Drosophila.

ABSTRACT: One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejected by the absence of a similar association between local recombination rate and nucleotide divergence between species. However, many recent studies show that recombination rates are often very different even in closely related species, questioning whether an association between recombination rate and divergence between species has been tested satisfactorily. To circumvent this problem, we directly surveyed recombination across approximately 43% of the D. pseudoobscura physical

SUBMITTER: McGaugh SE 

PROVIDER: S-EPMC3496668 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature