Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity.

ABSTRACT: Autophagy is a self-degradative process that involves turnover and recycling of cytoplasmic components in healthy and diseased tissue. Autophagy has been shown to be protective at the early stages of programmed cell death but it can also promote apoptosis under certain conditions. Earlier we demonstrated that oxygen contributes to the pathogenesis of neonatal brain damage, which can be ameliorated by intervention with recombinant human erythropoietin (rhEpo). Extrinsic- and intrinsic apoptotic pathways are involved in oxygen induced neurotoxicity but the role of autophagy in this model is unclear. We analyzed the expression of autophagy activity markers in the immature rodent brain after exposure to elevated oxygen concentrations. We observed a hyperoxia-exposure dependent regulation of au

SUBMITTER: Bendix I 

PROVIDER: S-EPMC3497305 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature