Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract.

ABSTRACT: Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control of fungal infections in both mice and humans; however, its role in the control of C. albicans colonization of the gastrointestinal tract has not been defined. Here, we demonstrate that in mice dectin-1 is essential for the control of gastrointestinal invasion during systemic infection, with dectin-1 deficiency associating with impaired fungal clearance and dysregulated cytokine production. Surprisingly, however, following oral infection, dectin-1 was not required for the control of mucosal coloni

SUBMITTER: Vautier S 

PROVIDER: S-EPMC3497410 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature