TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.

ABSTRACT:

Background

Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent.

Methods

We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed.

Results

Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs180047

SUBMITTER: Lu Y 

PROVIDER: S-EPMC3497590 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature