MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions.

ABSTRACT: It is widely held that any given virus uses only one type of nucleic acid for genetic information storage. However, this consensus has been challenged slightly by several recent studies showing that many RNA species are present within a range of DNA viruses that include Kaposi's sarcoma-associated herpesvirus (KSHV). RNAs extracted from purified DNA virus particles exhibit great diversity in terms of length, abundance, temporal expression, cellular localization, and coding capacity during viral infection. In addition to known RNA species, the current study showed that small regulatory RNAs were present in KSHV virions. A large number of viral and cellular microRNAs (miRNAs), as well as unusual small RNAs (usRNAs), were detected in KSHV virions by using deep sequencing. Both viral and host

SUBMITTER: Lin X 

PROVIDER: S-EPMC3497663 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature