Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.

ABSTRACT: The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.

SUBMITTER: Robinson PJ 

PROVIDER: S-EPMC3497735 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature