Genetic modifiers of nutritional status in cystic fibrosis.

ABSTRACT:

Background

Improved nutrition early in life is associated with better pulmonary function for patients with cystic fibrosis (CF). However, nutritional status is poorly correlated with the CFTR genotype.

Objective

We investigated the extent to which modifier genes influence nutrition in children with CF.

Design

BMI data were longitudinally collected from the CF Twin-Sibling Study and Cystic Fibrosis Foundation Patient Registry for twins and siblings from 2000 to 2010. A nutritional phenotype was derived for 1124 subjects by calculating the average BMI z score from 5-10 y of age (BMI-z(5to10)). The genetic contribution to the variation in BMI-z(5to10) (ie, heritability) was estimated by comparing the similarity of the phenotype in monozygous twins to that in dizygous twi

SUBMITTER: Bradley GM 

PROVIDER: S-EPMC3497925 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature