β-Carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descent.

ABSTRACT:

Background

Carotenoids have been hypothesized to reduce the risk of many diseases, but associations with intakes or blood concentrations may arise from other constituents of fruit and vegetables. Use of genetic variation in β-carotene 15,15'-monooxygenase 1 (BCMO1), a key enzyme in provitamin A carotenoid metabolism, as a surrogate for carotenoid exposure may aid in determining the role of carotenoids unconfounded by other carotenoid-containing food constituents, but important variants must be identified.

Objective

Our goal was to select BCMO1 single nucleotide polymorphisms (SNPs) that predict plasma carotenoid concentrations for use in future epidemiologic studies.

Design

We assessed the associations between 224 SNPs in BCMO1 ± 20 kb imputed from the 1000 Genomes Pr

SUBMITTER: Hendrickson SJ 

PROVIDER: S-EPMC3497927 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature