Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.

ABSTRACT:

Background

Choline is essential for fetal brain development, and it is not known whether a typical American diet contains enough choline to ensure optimal brain development.

Objective

The study was undertaken to determine whether supplementing pregnant women with phosphatidylcholine (the main dietary source of choline) improves the cognitive abilities of their offspring.

Design

In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholine (750 mg) or a placebo (corn oil) from 18 wk gestation through 90 d postpartum. Their infants (n = 99) were tested for short-term visuospatial memory, long-term episodic memory, language development, and global development at 10 and 12 mo of age.

Results

Th

SUBMITTER: Cheatham CL 

PROVIDER: S-EPMC3497930 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature