Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study.

ABSTRACT:

Background

Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother's intake but also by genetic variants carried by both the mother and the fetus. Associations between children's cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development.

Methods

We used a large population based study of women recruited during pregnancy to determine whether genetic variants in alcohol metabolising genes in this cohort of women and their children were r

SUBMITTER: Lewis SJ 

PROVIDER: S-EPMC3498109 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature