Dysplasia-carcinoma transition specific transcripts in colonic biopsy samples.

ABSTRACT:

Background

The early molecular detection of the dysplasia-carcinoma transition may enhance the strength of diagnosis in the case of colonic biopsies. Our aims were to identify characteristic transcript sets in order to develop diagnostic mRNA expression patterns for objective classification of benign and malignant colorectal diseases and to test the classificatory power of these markers on an independent sample set.

Methodology/principal findings

Colorectal cancer (CRC) and adenoma specific transcript sets were identified using HGU133plus2 microarrays and 53 biopsies (22 CRC, 20 adenoma and 11 normal). Ninety-four independent biopsies (27 CRC, 29 adenoma and 38 normal) were analyzed on microarrays for testing the classificatory power of the discriminatory genes. Array real-t

SUBMITTER: Galamb O 

PROVIDER: S-EPMC3498283 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature