Cyclooxygenase 2 gene polymorphisms and chronic periodontitis in a North Indian population: a pilot study.

ABSTRACT:

Purpose

Cyclooxygenase (COX) enzyme catalyzes the production of prostaglandins, which are important mediators of tissue destruction in periodontitis. Single nucleotide polymorphisms of COX2 enzyme have been associated with increasing susceptibility to inflammatory diseases. The present study evaluates the association of two single nucleotide polymorphisms in COX2 gene (-1195G>A and 8473C>T) with chronic periodontitis in North Indians.

Methods

Both SNPs and their haplotypes were used to explore the associations between COX2 polymorphisms and chronic periodontitis in 56 patients and 60 controls. Genotyping was done by polymerase chain reaction followed by restriction fragment length polymorphism. Chi-square test and logistic regression analysis were performed for association a

SUBMITTER: Daing A 

PROVIDER: S-EPMC3498299 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature