Increased cancer risks in myotonic dystrophy.

ABSTRACT:

Objective

To estimate cancer risks for patients with myotonic dystrophy, given that increased risks for neoplasms in association with myotonic dystrophy type 1 and type 2 have been suggested in several studies but the risks of cancers have not been quantified.

Patients and methods

A cohort of 307 patients with myotonic dystrophy identified from medical records of Mayo Clinic in Rochester, MN, from January 1, l993, through May 28, 2010, was retrospectively analyzed. We estimated standardized incidence ratios (SIRs) of specific cancers for patients with myotonic dystrophy compared with age- and sex-specific cancer incidences of the general population. Age-dependent cumulative risks were calculated using the Kaplan-Meier method.

Results

A total of 53 cancers were observe

SUBMITTER: Win AK 

PROVIDER: S-EPMC3498332 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature