Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study.

ABSTRACT:

Objectives

We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention.

Population and methods

A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1.

Results

At T0,

SUBMITTER: Lauria F 

PROVIDER: S-EPMC3498350 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature