Reprogramming of single-cell-derived mesenchymal stem cells into hair cell-like cells.

ABSTRACT:

Hypothesis

Adult mesenchymal stem cells (MSCs) can be converted into hair cell-like cells by transdetermination.

Background

Given the fundamental role sensory hair cells play in sound detection and the irreversibility of their loss in mammals, much research has focused on developing methods to generate new hair cells as a means of treating permanent hearing loss. Although MSCs can differentiate into multiple cell lineages, no efficient means of reprogramming them into sensory hair cells exists. Earlier work has shown that the transcription factor Atoh1 is necessary for early development of hair cells, but it is not clear whether Atoh1 can be used to convert MSCs into hair cells.

Methods

Clonal MSC cell lines were established and reprogrammed into hair cell-like cells

SUBMITTER: Lin Z 

PROVIDER: S-EPMC3498597 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature