Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain.

ABSTRACT: Every year thousands of people in the USA are diagnosed with small intestine and colorectal cancers (CRC). Although environmental factors affect disease etiology, uncovering underlying genetic factors is imperative for risk assessment and developing preventative therapies. Familial adenomatous polyposis is a heritable genetic disorder in which individuals carry germ-line mutations in the adenomatous polyposis coli (APC) gene that predisposes them to CRC. The Apc ( Min ) mouse model carries a point mutation in the Apc gene and develops polyps along the intestinal tract. Inbred strain background influences polyp phenotypes in Apc ( Min ) mice. Several Modifier of Min (Mom) loci that alter tumor phenotypes associated with the Apc ( Min ) mutation have been identified to date. We scre

SUBMITTER: Nnadi SC 

PROVIDER: S-EPMC3499057 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature