This Deja vu feeling--analysis of multidomain protein evolution in eukaryotic genomes.

ABSTRACT: Evolutionary innovation in eukaryotes and especially animals is at least partially driven by genome rearrangements and the resulting emergence of proteins with new domain combinations, and thus potentially novel functionality. Given the random nature of such rearrangements, one could expect that proteins with particularly useful multidomain combinations may have been rediscovered multiple times by parallel evolution. However, existing reports suggest a minimal role of this phenomenon in the overall evolution of eukaryotic proteomes. We assembled a collection of 172 complete eukaryotic genomes that is not only the largest, but also the most phylogenetically complete set of genomes analyzed so far. By employing a maximum parsimony approach to compare repertoires of Pfam domains and their com

SUBMITTER: Zmasek CM 

PROVIDER: S-EPMC3499355 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature