First survey and functional annotation of prohormone and convertase genes in the pig.

ABSTRACT:

Background

The pig is a biomedical model to study human and livestock traits. Many of these traits are controlled by neuropeptides that result from the cleavage of prohormones by prohormone convertases. Only 45 prohormones have been confirmed in the pig. Sequence homology can be ineffective to annotate prohormone genes in sequenced species like the pig due to the multifactorial nature of the prohormone processing. The goal of this study is to undertake the first complete survey of prohormone and prohormone convertases genes in the pig genome. These genes were functionally annotated based on 35 gene expression microarray experiments. The cleavage sites of prohormone sequences into potentially active neuropeptides were predicted.

Results

We identified 95 unique prohormone gene

SUBMITTER: Porter KI 

PROVIDER: S-EPMC3499383 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature