MK3 controls Polycomb target gene expression via negative feedback on ERK.

ABSTRACT:

Unlabelled

Background

Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation during differentiation. Molecular insight in processes that control dynamic chromatin association and dissociation of Polycomb repressive complexes during and beyond development is limited. We recently showed that MK3 interacts with Polycomb repressive complex 1 (PRC1). The functional relevance of this interaction, however, remained poorly understood. MK3 is activated downstream of mitogen- and stress-activated protein kinases (M/SAPKs), all of which fulfill crucial roles during development. We here use activation of the immediate-early response gene AT

SUBMITTER: Prickaerts P 

PROVIDER: S-EPMC3499388 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature