Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells.

ABSTRACT:

Background

Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression and are related with prognosis in various types of cancer including breast cancer. Recently, the gene encoding rab31 was found to be overexpressed in estrogen receptor-positive breast cancer tissue. In a previous study we found a significant association of high rab31 mRNA expression with poor prognosis in node-negative breast cancer patients. In the present study, we aimed to investigate the impact of rab31 (over)-expression on important aspects of tumor progression in vitro and in vivo.

Methods

Breast cancer cells displaying low (MDA-MB-231) or no (CAMA-1) endoge

SUBMITTER: Grismayer B 

PROVIDER: S-EPMC3499445 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature