Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

ABSTRACT:

Objectives

To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.

Methods

The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years.

Results

Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callo

SUBMITTER: Kalincik T 

PROVIDER: S-EPMC3499512 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature