A vaccine strategy that protects against genital herpes by establishing local memory T cells.

ABSTRACT: Most successful existing vaccines rely on neutralizing antibodies, which may not require specific anatomical localization of B cells. However, efficacious vaccines that rely on T cells for protection have been difficult to develop, as robust systemic memory T-cell responses do not necessarily correlate with host protection. In peripheral sites, tissue-resident memory T cells provide superior protection compared to circulating memory T cells. Here we describe a simple and non-inflammatory vaccine strategy that enables the establishment of a protective memory T-cell pool within peripheral tissue. The female genital tract, which is a portal of entry for sexually transmitted infections, is an immunologically restrictive tissue that prevents entry of activated T cells in the absence of inflamma

SUBMITTER: Shin H 

PROVIDER: S-EPMC3499630 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature