Evolutionary Adaptations of Plant AGC Kinases: From Light Signaling to Cell Polarity Regulation.

ABSTRACT: Signaling and trafficking over membranes involves a plethora of transmembrane proteins that control the flow of compounds or relay specific signaling events. Next to external cues, internal stimuli can modify the activity or abundance of these proteins at the plasma membrane (PM). One such regulatory mechanism is protein phosphorylation by membrane-associated kinases, several of which are AGC kinases. The AGC kinase family is one of seven kinase families that are conserved in all eukaryotic genomes. In plants evolutionary adaptations introduced specific structural changes within the AGC kinases that most likely allow modulation of kinase activity by external stimuli (e.g., light). Starting from the well-defined structural basis common to all AGC kinases we review the current knowledge on t

SUBMITTER: Rademacher EH 

PROVIDER: S-EPMC3499706 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature