Inferring separate parental admixture components in unknown DNA samples using autosomal SNPs.

ABSTRACT: The identification of ancestral admixture proportions for human DNA samples has recently had success in forensic cases. Current methods infer admixture proportions for the target sample, but not for their parents, which provides an additional layer of information that may aid certain forensic investigations. We describe new maximum likelihood methods (LEAPFrOG and LEAPFrOG Expectation Maximisation), for inferring both an individual's admixture proportions and the admixture proportions possessed by the unobserved parents, with respect to two or more source populations, using single-nucleotide polymorphism data typed only in the target individual. This is achieved by examining the increase in heterozygosity in the offspring of parents who are from different populations or who represent diffe

SUBMITTER: Crouch DJ 

PROVIDER: S-EPMC3499753 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature