Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk.

ABSTRACT:

Objective

Diminished serum paraoxonase and arylesterase activities (measures of paraoxonase-1 [PON-1] function) in humans have been linked to heightened systemic oxidative stress and atherosclerosis risk. The clinical prognostic use of measuring distinct PON-1 activities has not been established, and the genetic determinants of PON-1 activities are not known.

Methods and results

We established analytically robust high-throughput assays for serum paraoxonase and arylesterase activities and measured these in 3668 stable subjects undergoing elective coronary angiography without acute coronary syndrome and were prospectively followed for major adverse cardiovascular events (MACE= death, myocardial infarction, stroke) over 3 years. Low serum arylesterase and paraoxonase activitie

SUBMITTER: Tang WH 

PROVIDER: S-EPMC3499946 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature