Basic fibroblast growth factor enhances stemness of human stem cells from the apical papilla.

ABSTRACT:

Introduction

Stem cells from the apical papilla (SCAP) are a type of mesenchymal stem cells found in the developing tissue, apical papilla, of immature permanent teeth. Studies have shown that SCAP are likely to be a source of primary odontoblasts that are responsible for the formation of root dentin. Basic fibroblast growth factor (bFGF) is a signaling molecule and pleiotropic growth factor involved in tooth root development, and it promotes proliferation of a variety of cell types. The effects of bFGF on SCAP, however, have not been examined.

Methods

We investigated the regulatory effects of bFGF on the proliferation and differentiation potential of human SCAP in vitro. Changes in the cell cycle and proliferation, colony-forming unit-fibroblastic formation, alkaline phosph

SUBMITTER: Wu J 

PROVIDER: S-EPMC3499972 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature