Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

ABSTRACT:

Aims

Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual at elevating myocardial creatine levels. We therefore used mice overexpressing creatine transporter in the heart (CrT-OE) to test for the first time whether elevated creatine is beneficial in clinically relevant disease models of heart failure and ischaemia/reperfusion (I/R) injury.

Methods and results

CrT-OE mice were selected for left ventricular (LV) creatine 20-100% above wild-type values and subjected to acute and chronic coronary artery ligation. Increasing myocardial

SUBMITTER: Lygate CA 

PROVIDER: S-EPMC3500046 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature