Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.

ABSTRACT:

Aims

Establishing biochemical markers of pre-hypertension and early hypertension could help earlier diagnostics and therapeutic intervention. We assess dynamics of junctional adhesion molecule-A (JAM-A) expression in rat models of hypertension and test whether JAM-A expression could be driven by angiotensin (ANG) II and whether JAM-A contributes to the progression of hypertension. We also compare JAM-A expression in normo- and hypertensive humans.

Methods and results

In pre-hypertensive and spontaneously hypertensive rats (SHRs), JAM-A protein was overexpressed in the brainstem microvasculature, lung, liver, kidney, spleen, and heart. JAM-A upregulation at early and late stages was even greater in the stroke-prone SHR. However, JAM-A was not upregulated in leucocytes and pla

SUBMITTER: Xu H 

PROVIDER: S-EPMC3500047 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature