Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst.

ABSTRACT: Pd(II) insertion into β-methylene C(sp(3))-H bonds was enabled by a mutually repulsive and electron-rich quinoline ligand. Ligand tuning led to the development of a method that allows for installation of an aryl group on a range of acyclic and cyclic amides containing β-methylene C(sp(3))-H bonds.

SUBMITTER: Wasa M 

PROVIDER: S-EPMC3500088 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature