Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22.

ABSTRACT: Recent studies of haplotype diversity in a number of genomic regions have suggested that long stretches of DNA are preserved in the same chromosome, with little evidence of recombination events. The knowledge of the extent and strength of these haplotypes could become a powerful tool for future genetic analysis of complex traits. Different patterns of linkage disequilibrium (LD) have been found when comparing individuals of African and European descent, but there is scarce knowledge about the worldwide population stratification. Thus, the study of haplotype composition and the pattern of LD from a global perspective are relevant for elucidating their geographical stratification, as it may have implications in the future analysis of complex traits. We have typed 12 single nucleotide polymor

SUBMITTER: Gonzalez-Neira A 

PROVIDER: S-EPMC3500194 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature