The adjacent positioning of co-regulated gene pairs is widely conserved across eukaryotes.

ABSTRACT:

Background

Coordinated cell growth and development requires that cells regulate the expression of large sets of genes in an appropriate manner, and one of the most complex and metabolically demanding pathways that cells must manage is that of ribosome biogenesis. Ribosome biosynthesis depends upon the activity of hundreds of gene products, and it is subject to extensive regulation in response to changing cellular conditions. We previously described an unusual property of the genes that are involved in ribosome biogenesis in yeast; a significant fraction of the genes exist on the chromosomes as immediately adjacent gene pairs. The incidence of gene pairing can be as high as 24% in some species, and the gene pairs are found in all of the possible tandem, divergent, and convergent ori

SUBMITTER: Arnone JT 

PROVIDER: S-EPMC3500266 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature