Control of alternative pre-mRNA splicing by Ca(++) signals.

ABSTRACT: Alternative pre-mRNA splicing is a common way of gene expression regulation in metazoans. The selective use of specific exons can be modulated in response to various manipulations that alter Ca(++) signals, particularly in neurons. A number of splicing factors have also been found to be controlled by Ca(++) signals. Moreover, pre-mRNA elements have been identified that are essential and sufficient to mediate Ca(++)-regulated splicing, providing model systems for dissecting the involved molecular components. In neurons, this regulation likely contributes to the fine-tuning of neuronal properties.

SUBMITTER: Xie J 

PROVIDER: S-EPMC3500379 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature