Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients.

ABSTRACT:

Background

Low tidal volumes have been associated with improved outcomes in patients with established acute lung injury. The role of low tidal volume ventilation in patients without lung injury is still unresolved. We hypothesized that such a strategy in patients undergoing elective surgery would reduce ventilator-associated lung injury and that this improvement would lead to a shortened time to extubation

Methods

A single-center randomized controlled trial was undertaken in 149 patients undergoing elective cardiac surgery. Ventilation with 6 versus 10 ml/kg tidal volume was compared. Ventilator settings were applied immediately after anesthesia induction and continued throughout surgery and the subsequent intensive care unit stay. The primary endpoint of the study was time

SUBMITTER: Sundar S 

PROVIDER: S-EPMC3500383 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature