Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening.

ABSTRACT: There are many potential RNA drug targets in bacterial, viral, and human transcriptomes. However, there are few small molecules that modulate RNA function. This is due, in part, to a lack of fundamental understanding about RNA-ligand interactions including the types of small molecules that bind to RNA structural elements and the RNA structural elements that bind to small molecules. In an effort to better understand RNA-ligand interactions, we diversified the 2-aminobenzimidazole core (2AB) and probed the resulting library for binding to a library of RNA internal loops. We chose the 2AB core for these studies because it is a privileged scaffold for binding RNA based on previous reports. These studies identified that N-methyl pyrrolidine, imidazole, and propylamine diversity elements at the

SUBMITTER: Velagapudi SP 

PROVIDER: S-EPMC3500435 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature