Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.

ABSTRACT: Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are commonly found in genes that encode for synaptic proteins. However, it remains unclear how mutations that disrupt synapse function impact intellectual ability. In the SYNGAP1 mouse model of ID/ASD, we found that dendritic spine synapses develop prematurely during the early postnatal period. Premature spine maturation dramatically enhanced excitability in the developing hippocampus, which corresponded with the emergence of behavioral abnormalities. Inducing SYNGAP1 mutations after critical developmental windows closed had minimal impact on spine synapse function, whereas repairing these pathogenic mutations in adulthood did not improve behavior and cognition. These data demonstrate that SynGAP protein a

SUBMITTER: Clement JP 

PROVIDER: S-EPMC3500766 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature