The intrinsically disordered N-terminal region of AtREM1.3 remorin protein mediates protein-protein interactions.

ABSTRACT: The longstanding structure-function paradigm, which states that a protein only serves a biological function in a structured state, had to be substantially revised with the description of intrinsic disorder in proteins. Intrinsically disordered regions that undergo a stimulus-dependent disorder-to-order transition are common to a large number of signaling proteins. However, little is known about the functionality of intrinsically disordered regions in plant proteins. Here we investigated intrinsic disorder in a plant-specific remorin protein that has been described as a signaling component in plant-microbe interactions. Using bioinformatic, biochemical, and biophysical approaches, we characterized the highly abundant remorin AtREM1.3, showing that its N-terminal region is intrinsically diso

SUBMITTER: Marin M 

PROVIDER: S-EPMC3501056 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature