Pathways involved in sasang constitution from genome-wide analysis in a Korean population.

ABSTRACT:

Objective

Sasang constitution (SC) medicine, a branch of Korean traditional medicine, classifies the individual into one of four constitutional types (Taeum, TE; Soeum, SE; Soyang, SY; and Taeyang, TY) based on physiologic characteristics. The authors of the current article recently reported individual genetic elements associated with SC types via genome-wide association (GWA) analysis. However, to understand the biologic mechanisms underlying constitution, a comprehensive approach that combines individual genetic effects was applied.

Design

Genotypes of 1222 subjects of defined constitution types were measured for 341,998 genetic loci across the entire genome. The biologic pathways associated with SC types were identified via GWA analysis using three different algorithms--n

SUBMITTER: Kim BY 

PROVIDER: S-EPMC3501090 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature