Asthma symptom utility index: reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients.

ABSTRACT:

Background

The evaluation of asthma symptoms is a core outcome measure in asthma clinical research. The Asthma Symptom Utility Index (ASUI) was developed to assess the frequency and severity of asthma symptoms. The psychometric properties of the ASUI are not well characterized, and a minimal important difference (MID) is not established.

Objectives

We assessed the reliability, validity, and responsiveness to change of the ASUI in a population of adult asthmatic patients. We also sought to determine the MID for the ASUI.

Methods

Adult asthmatic patients (n = 1648) from 2 previously completed multicenter randomized trials were included. Demographic information, spirometric results, ASUI scores, and other asthma questionnaire scores were obtained at baseline and during f

SUBMITTER: Bime C 

PROVIDER: S-EPMC3501248 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature