Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

ABSTRACT:

Context

Although multivitamins are used to prevent vitamin and mineral deficiency, there is a perception that multivitamins may prevent cardiovascular disease (CVD). Observational studies have shown inconsistent associations between regular multivitamin use and CVD, with no long-term clinical trials of multivitamin use.

Objective

To determine whether long-term multivitamin supplementation decreases the risk of major cardiovascular events among men.

Design, setting, and participants

The Physicians' Health Study II, a randomized, double-blind, placebo-controlled trial of a common daily multivitamin, began in 1997 with continued treatment and follow-up through June 1, 2011. A total of 14,641 male US physicians initially aged 50 years or older (mean, 64.3 [SD, 9.2] years)

SUBMITTER: Sesso HD 

PROVIDER: S-EPMC3501249 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature