A functional selection model explains evolutionary robustness despite plasticity in regulatory networks.

ABSTRACT: Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing the extent of this plasticity and its functional implications has been challenging due to limited experimental data and the noisy nature of computational predictions. Here, we introduce a novel approach to study cis-regulatory evolution, and use it to trace the regulatory history of 88 DNA motifs of transcription factors across 23 Ascomycota fungi. While motifs are conserved, we find a pervasive gain and loss in the regulation of their target genes. Despite this turnover, the biological processes associated with a motif are generally conserved. We explain these trends using

SUBMITTER: Habib N 

PROVIDER: S-EPMC3501536 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature