Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.

ABSTRACT: With the use of risk-directed therapy for childhood acute lymphoblastic leukemia (ALL), outcome has improved dramatically in the past 40 years. However, a substantial portion of patients, many of whom have no known risk factors, experience relapse. Taking a genome-wide approach, in the present study, we evaluated the relationships between genotypes at 444 044 single nucleotide polymorphisms (SNPs) with the risk of relapse in 2535 children with newly diagnosed ALL after adjusting for genetic ancestry and treatment regimen. We identified 134 SNPs that were reproducibly associated with ALL relapse. Of 134 relapse SNPs, 133 remained prognostic after adjusting for all known relapse risk factors, including minimal residual disease, and 111 were significant even among patients who were negative f

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC3501717 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature