Ontology highlight
ABSTRACT:
SUBMITTER: Sexauer A
PROVIDER: S-EPMC3501718 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sexauer Amy A Perl Alexander A Yang Xiaochuan X Borowitz Michael M Gocke Christopher C Rajkhowa Trivikram T Thiede Christian C Frattini Mark M Nybakken Grant E GE Pratz Keith K Karp Judith J Smith B Douglas BD Levis Mark M
Blood 20120925 20
A hallmark of cancer is the disruption of differentiation within tumor cells. Internal tandem duplication mutations of the FLT3 kinase (FLT3/ITD) occur commonly in acute myeloid leukemia (AML) and are associated with poor survival, leading to efforts to develop FLT3 kinase inhibitors. However, FLT3 inhibitors have thus far met with limited success, inducing only a clearance of peripheral blasts with minimal BM responses. Quizartinib is a novel potent and selective FLT3 inhibitor currently being ...[more]