Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.

ABSTRACT: BACKGROUND:Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known. METHODS:Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up. RESULTS:We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36). CONCLUSION:We did not find any associations between food or nutrient intake and CLL/SLL. IMPACT:Our large prospective study indicates that diet may not play a role in CLL/SLL development.

SUBMITTER: Tsai HT 

PROVIDER: S-EPMC3501724 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature