Regeneration of the elbow joint in the developing chick embryo recapitulates development.

ABSTRACT: Synovial joints are among the most important structures that give us complex motor abilities as humans. Degenerative joint diseases, such as arthritis, cause loss of normal joint functioning and affect over 40 million people in the USA and approximately 350 million people worldwide. Therapies based on regenerative medicine hold the promise of effectively repairing or replacing damaged joints permanently. Here, for the first time, we introduce a model for synovial joint regeneration utilizing the chick embryo. In this model, a block of tissue that contains the prospective elbow is excised, leaving a window with strips of anterior and posterior tissue intact (window excision, WE). In contrast, we also slice out the same area containing the elbow and the distal piece of the limb is pinned bac

SUBMITTER: Ozpolat BD 

PROVIDER: S-EPMC3501998 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature