Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease.

ABSTRACT:

Background

Several lines of evidence support a pathophysiological role of immunity in atherosclerosis. Tyrosine-nitrated proteins, a footprint of oxygen- and nitrogen-derived oxidants generated by cells of the immune system, are enriched in atheromatous lesions and in circulation of patients with coronary artery disease (CAD). However, the consequences of possible immune reactions triggered by the presence of nitrated proteins in subjects with clinically documented atherosclerosis have not been explored.

Methods and results

Specific immunoglobulins that recognize 3-nitrotyrosine epitopes were identified in human lesions, as well as in circulation of patients with CAD. The levels of circulating immunoglobulins against 3-nitrotyrosine epitopes were quantified in patients with

SUBMITTER: Thomson L 

PROVIDER: S-EPMC3501999 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature